| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Resistance to Antimicrobial Peptides in Vibrios
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| Autores: |
Destoumieux-garzón, Delphine
Duperthuy, Marylise
Vanhove, Audrey
Schmitt, Paulina
Wai, Sun
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| Data: |
2014-12
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| Ano: |
2014
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| Palavras-chave: |
Vibrio
Lipopolysaccharide
Outer membrane vesicle
Membrane transporter
Innate immunity
Defensin
Cathelicidin
Bactericidal/permeability-increasing protein
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| Resumo: |
Vibrios are associated with a broad diversity of hosts that produce antimicrobial peptides (AMPs) as part of their defense against microbial infections. In particular, vibrios colonize epithelia, which function as protective barriers and express AMPs as a first line of chemical defense against pathogens. Recent studies have shown they can also colonize phagocytes, key components of the animal immune system. Phagocytes infiltrate infected tissues and use AMPs to kill the phagocytosed microorganisms intracellularly, or deliver their antimicrobial content extracellularly to circumvent tissue infection. We review here the mechanisms by which vibrios have evolved the capacity to evade or resist the potent antimicrobial defenses of the immune cells or tissues they colonize. Among their strategies to resist killing by AMPs, primarily vibrios use membrane remodeling mechanisms. In particular, some highly resistant strains substitute hexaacylated Lipid A with a diglycine residue to reduce their negative surface charge, thereby lowering their electrostatic interactions with cationic AMPs. As a response to envelope stress, which can be induced by membrane-active agents including AMPs, vibrios also release outer membrane vesicles to create a protective membranous shield that traps extracellular AMPs and prevents interaction of the peptides with their own membranes. Finally, once AMPs have breached the bacterial membrane barriers, vibrios use RND efflux pumps, similar to those of other species, to transport AMPs out of their cytoplasmic space.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00276/38767/37308.pdf
DOI:10.3390/antibiotics3040540
http://archimer.ifremer.fr/doc/00276/38767/
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| Editor: |
MDPI AG
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| Formato: |
application/pdf
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| Fonte: |
Antibiotics (2079-6382) (MDPI AG), 2014-12 , Vol. 3 , N. 4 , P. 540-563
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| Direitos: |
2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
info:eu-repo/semantics/openAccess
restricted use
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